The α-hydroxy-n-fatty acids of yeast cerebrin

Poly(α-hydroxy Acids)-Based Cell Microcarriers

Biodegradable poly(α-hydroxyacids) have gained increasing interest in the biomedical field for their use as cell microcarriers thanks to their biodegradability, biocompatibility, tunable mechanical properties/degradation rates and processability. The synthesis of these poly(α-hydroxyacids) can be finely controlled to yield (co)polymers of desired mechanical properties and degradation rates. On ...

Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids.

In the present study, to investigate the contribution of n-3 PUFAs in the oxidative modification of protein in vivo, we characterize the covalent binding of 4-hydroxy-2-hexenal (HHE), a potent cytotoxic aldehyde originating from the peroxidation of n-3 PUFAs, to protein and describe the production of this aldehyde in oxidatively modified LDL and in human atherosclerotic lesions. Upon incubation...

Isolation and determination methods for brain cerebrosides, hydroxy fatty acids, and unsaturated and saturated fatty acids *

A new method is described for the isolation of nearly pure total cerebrosides from fresh brain. Florisil columns are used to separate the cerebroside hydroxy and normal acids, in the form of their esters, and to separate the saturated and unsaturated esters of each group. The esters within each class are determined by gas chromatography, the hydroxy esters being run as the methyl ethers. Yields...

Reactivity of α-hydroxy Acids towards Piperidinium Chlorochromate Oxidation

The kinetics of oxidations of α-hydroxy acids such as glycolic acid, lactic acid and mandelic acids with piperidiniumchlorochromate has been studied in aqueous acetic acid medium. The reaction order is one with respect to oxidant, substrate and fractional order with respect to hydrogen ion concentration. Decrease in dielectric constant of the medium increases the rate of reaction. No appreciabl...

Occurrence of 2-hydroxy Fatty Acids in Animal Tissues.